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nexus.study / neuroscience-101
Chapter 4 · Synaptic plasticity

Generated notes

gen · 0.8s

Long-term potentiation (LTP) strengthens synapses through repeated, high-frequency stimulation — the cellular scaffold of learning.

key insight

NMDA receptors act as coincidence detectors: pre- and post-synaptic activity must overlap for LTP.

Ca²⁺ influx triggers CaMKII, which phosphorylates AMPA receptors and inserts more of them into the membrane —

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chapter-04-synapses.mdauto-synced
01## Synaptic plasticity
02The brain's ability to reshape its wiring via use.
03LTP strengthens, LTD weakens.
04Coincidence detector: NMDA
05Ca²⁺ → CaMKII → AMPA insertion
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Question · 8 of 24
What is long-term potentiation?
Next review in 3 days7.2× / 10
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NMDA receptors require both glutamate and depolarization
LTP is mediated exclusively by GABA
CaMKII phosphorylates AMPA receptors
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Why does a seizure sometimes enhance memory?
Briefly, abnormal hyper-synchronous firing triggers LTP-like changes in the hippocampus — though usually at the cost of...
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Understanding cellular mechanisms
Calcium signaling cascade
NMDA receptor dynamics
Long-term potentiation
Hippocampal circuits
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Drill · 14 of 40
Which receptor is the coincidence detector?
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